BB

BAKER BROS. ADVISORS LP

13F
BAKER BROS. ADVISORS LP
Last update 2025-03-20 93 Stocks (8 new)
Value $9.24 Bil Turnover 3 %
Countries:

BAKER BROS. ADVISORS LP Profile

Baker Bros. Advisors is a private hedge fund sponsor that is based out of New York City. The company was established in 2000 by Julian Baker and Felix Baker, who continues to have an active role in the company today acting as its co-managing members. Julian Baker has a business background from Harvard and Felix Baker has a PhD in Immunology from Stanford. The company currently has 25 employees with 11 of them being investment advisory professionals or researchers. Baker Bros. Advisors currently falls into the category of catering to less than 10 clients. The firm utilizes a fundamental driven approach to make its investment decisions, emphasizing life sciences companies. The company holds its investments usually for three years, although its more successful investments are held for longer. Baker Bros. Advisors invests almost exclusively in the health care sector, with a much lesser degree of assets allocated in the industrials sector. The firm’s top holdings currently include Pharmacyclics Inc., which alone makes up almost a fifth of its total asset allocations, Incyte Corporation, Synageva Biopharma Corporation, Seattle Genertics Inc., Salix Pharmaceuticals Inc., Acadia Pharmaceuticals Inc., and Biomarin Pharmaceuticals Inc., with its top ten holdings making up more than three quarters of its total holdings. Baker Bros. Baker Bros. Advisors does not believe in diversifying its portfolio, instead focusing on specific companies that it has deemed to be good holdings and placing concentrated positions in their securities that can generate significant returns in the long term. The company has a current market value of over $12 billion, investing almost all of its total available assets. Advisors’s market value has been increasing significantly over time, growing from its $5 billion market valuation just two years prior in 2013 to well over twice that amount today. Baker Bros. Advisors currently provides its products and services to a variety of university foundations, and families.
BAKER BROS. ADVISORS LP Top Holdings of 2024-12-31 View Full List
Ticker
Company
Shares
Value ($1000)
Shares Change %
Weighting %
Trade Impact %
% of Shares outstanding
3M Change %
YTD Change %
Market Cap $Mil
Industry
INCY
Incyte Corp
30,739,466
2,123,174.9
0%
22.980
0%
15.880
-20.03%
-16.03%
11,224.4
Biotechnology
ONC
BeiGene Ltd
9,531,880
1,760,633.6
-9.81%
19.060
-2.44%
8.930
+12.10%
+34.88%
28,987.3
Biotechnology
ACAD
ACADIA Pharmaceuticals Inc
42,877,916
786,809.8
0%
8.520
0%
25.770
-23.38%
-20.33%
2,438.4
Biotechnology
MDGL
Madrigal Pharmaceuticals Inc
1,974,590
609,299.2
0%
6.590
0%
9.050
-9.22%
+0.07%
6,818.2
Biotechnology
SMMT
Summit Therapeutics Inc
24,424,865
435,861.7
0%
4.720
0%
3.310
+34.81%
+86.21%
24,513.1
Biotechnology
RVMD
Revolution Medicines Inc
7,936,972
347,163.2
+4.86%
3.760
+0.17%
4.290
-8.99%
-14.40%
6,960.6
Biotechnology
INSM
Insmed Inc
5,006,863
345,673.8
+13.38%
3.740
+0.44%
2.800
-9.12%
+2.46%
12,861.9
Biotechnology
RYTM
Rhythm Pharmaceuticals Inc
6,084,249
340,596.3
-4.91%
3.690
-0.17%
9.900
+2.34%
+6.90%
3,783.3
Biotechnology
KYMR
Kymera Therapeutics Inc
5,995,929
241,216.2
0%
2.610
0%
9.260
-30.61%
-23.71%
1,993.1
Biotechnology
KOD
Kodiak Sciences Inc
17,310,490
172,239.4
0%
1.860
0%
32.900
-51.99%
-59.90%
210.5
Biotechnology

BAKER BROS. ADVISORS LP's Historical Top Holdings Breakdowns

BAKER BROS. ADVISORS LP's Top Stock Picks View Full List
Ticker
Company
Date
Action
Impact %
Price Range
Price
Price Change from Avrg%
Comment
Current Shares
Share Change
ONC
BeiGene Ltd2024-12-31Reduce
-2.44%
â—Ź
174.72 ($203.89) 246.04
$249.13
22.19%
Reduce -9.81%
9,531,880
-1,037,017
INSM
Insmed Inc2024-12-31Add
+0.44%
â—Ź
66.29 ($72.01) 76.65
$70.74
-1.76%
Add 13.38%
5,006,863
590,945
GRAL
GRAIL Inc2024-12-31New Buy
+0.31%
â—Ź
12.57 ($16.31) 23.62
$33.76
106.99%
New holding
1,630,125
1,630,125
CADL
Candel Therapeutics Inc2024-12-31New Buy
+0.28%
â—Ź
3.8 ($5.89) 9.96
$4.76
-19.19%
New holding
2,981,983
2,981,983
BCYC
Bicycle Therapeutics PLC2024-12-31Add
+0.23%
â—Ź
13.81 ($21.41) 27.51
$8.67
-59.50%
Add 15.8%
10,885,357
1,485,397
CRSP
CRISPR Therapeutics AG2024-12-31Add
+0.20%
â—Ź
38.65 ($47.25) 55.15
$38.54
-18.43%
Add 55.15%
1,308,011
464,936
RVMD
Revolution Medicines Inc2024-12-31Add
+0.17%
â—Ź
42.97 ($50.55) 60.6
$37.44
-25.93%
Add 4.86%
7,936,972
367,882
RYTM
Rhythm Pharmaceuticals Inc2024-12-31Reduce
-0.17%
â—Ź
47.2 ($55.29) 67.33
$59.84
8.23%
Reduce -4.91%
6,084,249
-314,117
IMVT
Immunovant Inc2024-12-31Add
+0.13%
â—Ź
23.88 ($28.36) 31.42
$14.45
-49.05%
Add 39.37%
1,707,881
482,471
ROIV
Roivant Sciences Ltd2024-12-31Add
+0.12%
â—Ź
11.16 ($11.83) 12.71
$10.73
-9.30%
Add 34.63%
3,767,773
969,057

BAKER BROS. ADVISORS LP Total Holding History ($B)

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BAKER BROS. ADVISORS LP's Asset Allocation

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BAKER BROS. ADVISORS LP Past Portfolios

Portfolio Date Number of Stocks New Stocks Total Value ($Mil) Q/Q Turnover

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BAKER BROS. ADVISORS LP's Hypothetical Growth since 2024-12-31

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