Ionis Pharmaceuticals is the leading developer of antisense technology to discover and develop novel drugs. Its broad clinical and preclinical pipeline targets a wide variety of diseases, with an emphasis on cardiovascular, metabolic, neurological, and rare diseases. Ionis and partner Biogen brought Spinraza to market in 2016 as a treatment for a rare neuromuscular disorder, spinal muscular atrophy, and Biogen launched ALS drug Qalsody in 2023. Ionis brought two additional drugs to market via its cardiovascular-focused subsidiary Akcea, including ATTR amyloidosis drug Tegsedi (2018) and cardiology drug Waylivra (Europe, 2019).

Financial Strength

4/10

Name	Current	Vs Industry
Cash-To-Debt	1.53
Equity-to-Asset	0.11
Debt-to-Equity	4.87
Debt-to-EBITDA	-5.54
Piotroski F-Score	4/9	0 1 2 3 4 5 6 7 8 9
Altman Z-Score	1.25	Distress Grey Safe
Beneish M-Score	-3.03	Manipulator Not Manipulator
WACC vs ROIC		WACC ROIC

Growth Rank

7/10

	Name	Current	Vs Industry		Vs History
	3-Year Revenue Growth Rate	1.7
	3-Year EBITDA Growth Rate	-27.4
	3-Year EPS without NRI Growth Rate	2.8
	3-Year FCF Growth Rate	-298.6
	3-Year Book Growth Rate	-20.3
	Future 3-5Y Total Revenue Growth Rate	12.9

Momentum Rank

8/10

	Name	Current	Vs Industry		Vs History
	5-Day RSI	14.43
	9-Day RSI	24.5
	14-Day RSI	30.7
	6-1 Month Momentum %	-8.96
	12-1 Month Momentum %	22.81

Liquidity Ratio

	Name	Current	Vs Industry		Vs History
	Current Ratio	7.37
	Quick Ratio	7.28
	Cash Ratio	6.73
	Days Inventory	969.73
	Days Payable	581.91

Dividend & Buy Back

	Name	Current	Vs Industry		Vs History
	3-Year Average Share Buyback Ratio	-0.9
	Shareholder Yield %	-4.14

Profitability Rank

3/10

	Name	Current	Vs Industry		Vs History
	Gross Margin %	98.72
	Operating Margin %	-50.1
	Net Margin %	-49.54
	FCF Margin %	-44.68
	ROE %	-100.54
	ROA %	-13.23
	ROIC %	-75.58
	ROC (Joel Greenblatt) %	-112.19
	ROCE %	-11.06
	Years of Profitability over Past 10-Year	3

GF Value Rank

6/10

	Name	Current	Vs Industry		Vs History
	PS Ratio	7.23
	PB Ratio	19.22
	Price-to-Tangible-Book	19.24
	EV-to-EBIT	-17.44
	EV-to-Forward-EBIT	-9.05
	EV-to-EBITDA	-18.94
	EV-to-Forward-EBITDA	-9.33
	EV-to-Revenue	6.36
	EV-to-Forward-Revenue	8.41
	EV-to-FCF	-14.31
	Price-to-Projected-FCF	13.69
	Price-to-Median-PS-Value	0.65
	Earnings Yield (Greenblatt) %	-5.73
	FCF Yield %	-6.06

GF Value: €36.62

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